Ezrin loss reduces downstream MAPK and Akt signaling, and represses mTORC1 signaling by promoting lysosomal localization of the TSC complex. An Ezrin mutant Medaka fish line is then generated to test ...

The findings are helpful for understanding EGF/mTOR signal transduction and support a critical role for the scaffolding protein Ezrin in the upstream regulation of EGFR/AKT activity, TSC subcellular ...

A research group from Nagoya City University has elucidated the significance of birth in the maintenance of neural stem cells (NSCs).The findings of the study are published in Science Advances.

They showed that RG transiently enter a neurogenic state via mTORC1 signaling in preterm birth mice. However, they also found that neurogenesis at the young-adult stage was decreased due to ...

Studies by Jeffrey Klomp et al. 6 and Jennifer Klomp et al. 7 refine our understanding of the signaling effects of oncogenic KRAS. The studies suggest that mutant KRAS signals predominantly ...

The mechanistic (or mammalian) target of rapamycin (mTOR) signaling pathway, implicated in rapid antidepressant effects, was investigated for its role in KNT-127's action. The researchers injected ...

This repository contains the standalone signaling server which can be used for Nextcloud Talk (https://apps.nextcloud.com/apps/spreed). See https://nextcloud-spreed ...