Combination treatment with ibrilatazar and chemotherapy has demonstrated “promising efficacy and safety” in patients with advanced squamous non-small cell lung cancer (NSCLC), according to researchers ...
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by repressing pro-leukemogenic programs, independent of the unfolded protein response. A treatment strategy for acute myeloid ...
Hosted on MSN27d
By listening, scientists learn how a protein foldsoffers an unprecedented view of the sequence of hydrogen-bonding events that occur when a protein morphs from an unfolded to a folded state. "A protein must fold properly to become an enzyme or ...
News Medical on MSN8d
How olive oil bioactives regulate genes linked to insulin resistanceOlive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...
News Medical on MSN9d
Study links low levels of PM2.5 exposure to liver damageA new study reveals that even low-dose, chronic exposure to air pollution can trigger liver inflammation, fibrosis, and metabolic disruptions, increasing the risk of fatty liver disease and other ...
Mysterious Blobs Found inside Cells Are Rewriting the Story of How Life Works Tiny specks called biomolecular condensates are ...
The Brighterside of News on MSN3d
Pythons can teach us a lot about human digestionIn the animal kingdom, the vertebrate intestine is renowned for its regenerative capacity, a vital process for maintaining ...
During the pathogenesis of Parkinson’s disease ... protein degradation (ERAD). Mnl1 demannosylates misfolded, globular proteins and Pdi1 then reduces the disulfides to generate unfolded proteins ...
In addition, the accumulation of abnormally processed CFTR in the endoplasmic reticulum results in unfolded protein responses that trigger ... predictive for the clinical course of CF lung disease is ...
BuzzFeed on MSN5d
I'm A Breast Cancer Doctor. Here's What I Didn't Know — Until I Was Diagnosed Myself.When I went to the hospital last year for my annual mammogram, I expected to be in and out in 60 minutes. Being a healthy ...
They found that RNA damage triggers a swift cellular response through a protein called ZAK-alpha ... The study revealed that two distinct processes unfolded: pyroptosis, a fiery and inflammatory ...
The endoplasmic reticulum can also detect unfolded proteins ... A β, Amyloid beta; AD, Alzheimer’s disease; BNIP3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Drp1, Dynamin-1-like ...
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