Care was taken to minimise the confounding effects of hypoxia. Weaknesses: The authors suggest that shear stress activates the mTORC2-PKC-Notch signalling pathway by altering the membrane lipid ...

Notch1 is expressed uniformly throughout the mouse endocardium during the initial stages of heart valve formation, yet it remains unclear how Notch signaling ... pathway involving post-translational ...

RTK receptors mediate outside signals to the interior ... which activates several intracellular cascades including MAPK, PLC/PKC, SRC, JAK/STAT, and PI3K/AKT. These signaling pathways induce ...

Simplified schematic of neural, hormonal, redox, and immune signaling pathways activated in adrenal chromaffin cells ... Protein Kinase A; NO, Nitric Oxide; PKC, Protein Kinase C; GC, Guanylyl Cyclase ...

The distinct population of endothelial cells that line blood vessels in the insulin-producing "islets" of the human pancreas ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...

New research shows that a network of subcellular structures similar to those responsible for propagating molecular signals that make muscles contract are also responsible for transmitting signals in ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, ...

In a video interview, William K. Oh, MD, director of precision medicine at Yale Cancer Center and Smilow Cancer Hospital discusses the latest breakthroughs in advanced prostate cancer treatment.