Previous work has shown that the protein kinase C (PKC)–modulating drug bryostatin ... downregulating proinflammatory pathways and promoting regenerative and protective programs.

In contrast, when MnSOD transgenic mice are made diabetic, there is no activation of any of the four pathways. In endothelial cells, PKC also activates nuclear factor κB (NFκB), a transcription ...

Ideaya is financially strong, with $1.2 billion in cash reserves, sufficient to fund operations into at least 2028. Click ...

A new chemical compound has been making a big impression in the fight against cancer in recent years. Now it seems EBC-46, ...

Nature 414:813-820, 2001. Consequences of hyperglycemia-induced activation of PKC. Hyperglycemia increases flux through the hexosamine pathway. From Brownlee M: Biochemistry and molecular cell ...

To answer this question, the authors use a combination of in vivo and ex vivo experiments to demonstrate the critical role of hemodynamic forces on Notch1 activation and provide strong evidence for a ...

Notch signaling has been identified as a key regulatory pathway in patterning the endocardium through ... which activated mTORC2 and PKC and promoted Notch1 cleavage even in the absence of strong ...

Numerous cellular processes rely on PKC, and many are involved with major diseases including ... These agents kickstart certain pathways in latent cells infected by the virus. Latent cells act as a ...

A compound with the unpresuming designation of EBC-46 has made a splash in recent years for its cancer-fighting prowess. Now a new study led by Stanford researchers has revealed that EBC-46 also shows ...

Negative feedback pathways, depicted by dashed lines ... Protein Kinase A; NO, Nitric Oxide; PKC, Protein Kinase C; GC, Guanylyl Cyclase. Whether the responses of medullary cells to cytokines ...