Taken together, these data indicate that POLG mutations induced astrocytic mitophagy failure by regulating the AKT/mTOR/AMPK/ULK1 signaling pathway. Nicotinamide Riboside and Metformin Treatment ...

SMILE modulated mTOR-STAT3 signaling and reduced the production of proinflammatory cytokines, such as IL-6, IL-1β, and IL-17, in the colon. Metformin increased the levels of SMILE, AMPK, and Foxp3 but ...

Advances in multi-omics, artificial intelligence (AI), deep learning (DL), ageing biomarkers, precision imaging, ageing clocks, robotics, and smart technologies have enabled researchers to ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.