In the talk, Sanil Bhatia moved from the function of HSP90 in cancer cells to inhibitors that target HSP90. He highlighted inhibitors that target the dimerization of HSP90 as these are designed to ...
Kosan Biosciences has initiated a Phase I multicenter trial of an oral formulation of KOS-1022 (DMAG), a second-generation heat shock protein 90 (Hsp90) inhibitor. KOS-1022 is the first-reported Hsp90 ...
Design, Synthesis, and Biological Evaluation of Chiral-Proline Derivatives as Novel HSP90 Inhibitors
Laboratory for Food and Medicine Homologous Natural Resources Development and Utilization, Dezhou University, Dezhou City 253023, Shandong Province, China ...
Novel combination strategies are urgently needed to enhance efficiency of MWA. Conclusions: In this study, we found that the XIAP inhibitor AZD5582 modulates the immune microenvironment and inhibits ...
In addition, organoids with high Eif5a2 expression were shown to be sensitive to AKT inhibitors. As a final step, the team analysed two databases of human prostate cancer samples, which confirmed a ...
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