Mechanically, FGFR3 deficiency promoted macrophage chemotaxis partly through activation of NF-κB/CXCR7 pathway. Inhibition of CXCR7 could significantly reverse FGFR3-deficiency-enhanced macrophage ...

They can significantly decrease the invasiveness of bladder cancer cells, making them especially suitable for patients with FGFR3 mutations or abnormal activation of the MAPK pathway. Immune ...

We observed hyperphosphorylation of kinases such as Serine/threonine-protein kinase 3 (STK3/NDR1), Microtubule affinity-regulating kinase 2 (MARK2), mammalian Ste20-like protein kinase 3 (MST3), ...

The Employees’ Provident Fund Organisation (EPFO) has extended the deadline for activating the Universal Account Number (UAN) and linking it with Aadhaar to January 15, 2025. This extension ...

The Company's lead precision medicine stemming from SNÅP, TYRA-300, is a potential first-in-class selective FGFR3 inhibitor that is designed to avoid the toxicities associated with inhibition of ...

In this connection, the competent authority has granted an extension of timeline from 15.12.2024 to 15.01.2025 for UAN activation and Aadhaar seeding in bank account of all the employees,” said ...

This guide will walk you through everything you need to know about UAN, its benefits, features, and the step-by-step process to activate it on the EPFO portal. The Universal Account Number (UAN ...

Commissions do not affect our editors' opinions or evaluations. Before you can use a new credit card, you’ll have to activate it by following the included instructions when it arrives.

Over the last years, many biological markers emerged that act as an adjunct for the detection of early bladder cancer recurrence. Some of these markers had a proven better sensitivity and ...

A year earlier ImmunoGen revealed that the alliance had yielded three candidates, including one ADC directed at fibroblast growth factor receptor 3 (FGFR3) associated with bladder and brain ...