We have developed a non-radioactive flow-cytometry assay to monitor and quantify the target-cell killing activities mediated by cytotoxic T lymphocytes (CTLs). This flow-cytometry CTL (FCC ...

Using a mouse model in which tumors show a growth-regression-recurrence pattern, we investigated the mechanisms for down-regulation of cytotoxic T lymphocyte–mediated tumor immuno-surveillance.

The basis of peptide vaccination is the observation that leukemia cells can act as antigen-presenting cells (APCs) that cleave endogenous leukemia antigens in their proteasome and present them on ...