In MYCN-amplified NB cells, the half-life of N-Myc is significantly prolonged due to binding and stabilization by Aurora kinase A (Aurora-A; elevated in NB), resulting in increased steady-state ...

Their results are published in Chemical Science. Lead researcher Professor Andrew Wilson explained, "Aurora-A is an incomplete kinase, which means it relies on protein-protein interactions to ...

Puma Biotechnology will issue its 4Q and full year 2024 results on Feb. 27 and follow with a conference call at 1:30 p.m.

Image Source: Zacks Investment Research Puma Biotechnology in-licensed global development and commercialization rights for alisertib, an aurora kinase A inhibitor, from Japan’s Takeda in 2022.

Cell cycle events are controlled tightly by several kinase families including CDKs, Plks, and Aurora kinases. What is interesting about these kinases is that they don't always act alone.