Negative feedback pathways, depicted by dashed lines ... Acetylcholine, pituitary adenylate cyclase-activating peptide, and other neurotransmitters are released from synaptic terminals. Cytokines, ...

Background: Pituitary adenylate cyclase-activating polypeptide (PACAP ... Wnt/β-catenin is a common downstream target pathway of SOX6. We speculated that PACAP38 may suppress Wnt/β-catenin signaling ...

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These pathways represent the targets of all currently approved ... discovered in the gut that mediates smooth muscle relaxation via activation of adenylate cyclase and generation of cAMP. Despite ...

With the approval of the soluble guanylate cyclase stimulator riociguat, an additional drug class has become available targeting a distinct molecular target in the same pathway as PDE5 inhibitors.

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Expert Rev Clin Pharmacol. 2012;5(3):319-336. Finally, a recent study suggested that although prasugrel significantly reduces thrombotic events in patients with ACS undergoing PCI because of its ...

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During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...