IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by repressing pro-leukemogenic programs, independent of the unfolded protein response. A treatment strategy for acute myeloid ...

offers an unprecedented view of the sequence of hydrogen-bonding events that occur when a protein morphs from an unfolded to a folded state. "A protein must fold properly to become an enzyme or ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

A new study reveals that even low-dose, chronic exposure to air pollution can trigger liver inflammation, fibrosis, and metabolic disruptions, increasing the risk of fatty liver disease and other ...

I Herantis Pharma Plc ("Herantis"), a company developing disease-modifying therapies for Parkinson’s disease, is pleased to announce an ...

In the animal kingdom, the vertebrate intestine is renowned for its regenerative capacity, a vital process for maintaining ...

Mysterious Blobs Found inside Cells Are Rewriting the Story of How Life Works Tiny specks called biomolecular condensates are ...

In addition, the accumulation of abnormally processed CFTR in the endoplasmic reticulum results in unfolded protein responses that trigger ... predictive for the clinical course of CF lung disease is ...

When I went to the hospital last year for my annual mammogram, I expected to be in and out in 60 minutes. Being a healthy ...

They found that RNA damage triggers a swift cellular response through a protein called ZAK-alpha ... The study revealed that two distinct processes unfolded: pyroptosis, a fiery and inflammatory ...

In 2017, a tragic incident unfolded in a Nevada hospital. A woman, admitted for pneumonia, tragically succumbed to multiple ...

In the wake of the worst U.S. aviation incident since 2001, as authorities hunt for answers, victims’ families share wrenching stories of love and loss Johnny Dodd is a senior writer at PEOPLE ...