A recent study in an animal model provides direct evidence for the role of the vagus nerve in gut microbiome-brain ...

The distinct population of endothelial cells that line blood vessels in the insulin-producing "islets" of the human pancreas ...

Dr. Marwan G. Fakih explains that KRAS mutations, found in 45% of patients with colorectal cancer, include the rare KRAS G12C mutation, leading to Lumakras approval.

Scientists uncover an enzyme that boosts cancer cell metabolism to fuel growth. The enzyme, GUK1, supports metabolism in cancer cells to help tumors grow.

Lung cancer is a particularly challenging form of cancer. It often strikes unexpectedly and aggressively with little warning, and it can shapeshift in unpredictable ways to evade treatment.

Elevated PKA competitively inhibits PDE9A degradation, with PDE9A accumulation further disrupting the balance between cGMP-cAMP signalling pathways. PDE9A inhibition via Bay 73-6691 or CHIP ...

This is a useful study that adds new data to how different DAG pools influence cellular signaling, and dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from ...

Figure 4. Psi1-Plc1-Dip2 triad axis regulates selective DAG subspecies to modulate PKC signalling. (A) Schematic showing various pathways (green arrows) that feed into the production of DAGs in the ...