A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell.

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals ...

Merck Sharp & Dohme LLC has identified targeted activator of cell kill (TACK) compounds acting as Gag polyprotein (HIV-1)/protein Pol dimerization inducers reported to be useful for the treatment of ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell.

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...

Thurner syndrome (MTS) is a clinicopathological condition where the left common iliac vein is compressed by the overlying right common iliac artery, potentially leading to deep vein thrombosis (DVT) ...

We report that FHR-B is a dimeric protein resembling human FHR-1, FHR-2 and FHR-5, but involving a different dimerization domain with distinct structural and functional characteristics. Our studies ...

We hypothesized that incorporation of ERMS data into multimeric protein structure prediction would significantly ... 1fgb_pdbs/: 1,000 pdb structures of 1fgb (only the dimer form is present in the ...

We synthesized a geranyl dimer that binds to the central pocket with micromolar affinity, and dimeric peptides that bind the spike-tip pocket with sub-micromolar affinity. Cryo-electron microscopy ...

HAP is a representative example of a canonical CAM, that targets a hydrophobic pocket mediating HBc-dimer multimerization, an essential step in capsid assembly. A blue arrow indicates how dimeric ...