Ideaya is financially strong, with $1.2 billion in cash reserves, sufficient to fund operations into at least 2028. Click ...

A new chemical compound has been making a big impression in the fight against cancer in recent years. Now it seems EBC-46, ...

In contrast, when MnSOD transgenic mice are made diabetic, there is no activation of any of the four pathways. In endothelial cells, PKC also activates nuclear factor κB (NFκB), a transcription ...

The primary culprits, matrix metalloproteinase (MMP)-9 and protein kinase C (PKC)-βII, are responsible for impaired angiogenesis, NETosis, and ECM degradation. Thus, interest in identifying selective ...

Meanwhile, previous research has shown that metformin contributes to the regulation of endothelial cell function triggered by high glucose via the autophagy pathway (14). To determine the roles of ...

Participants from the West Ham United Foundation’s Player Pathway programme were recently surprised by a visit from Academy players Ollie Scarles, Kaelan Casey and Fin Herrick. Boys from the U12s, ...

Dr Caroline Sandford, climate scientist at the Met Office Hadley Centre. The rate at which atmospheric CO2 is increasing is now outpacing the pathways set out by the Intergovernmental Panel on Climate ...

To answer this question, the authors use a combination of in vivo and ex vivo experiments to demonstrate the critical role of hemodynamic forces on Notch1 activation and provide strong evidence for a ...

Notch signaling has been identified as a key regulatory pathway in patterning the endocardium through ... which activated mTORC2 and PKC and promoted Notch1 cleavage even in the absence of strong ...

Intracellular kinases play a ubiquitous role in signaling pathways within cells. Receptor tyrosine kinases function at the beginning of a number of signal transduction cascades, whereas ...