The PDGF-signaling pathway stimulates tumor-cell proliferation, angiogenesis, and pericyte recruitment to tumor blood vessels. [9] Interestingly, a recent report showed that PDGF-BB expression is ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated ... 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways.

MAA and citrullinated fibrinogen can lead to macrophages secreting PDGF-BB, promoting invasive FLS differentiation. In RA-FLS cells, stimulation of cGAS by METs from HP-1 cells activates the PI3K/Akt ...

However, how these signaling pathways intertwine and distinctively regulate MPC pool ... (Peprotech, Cranbury, NJ), PDGF-BB (1/5/15 ng/mL) (R&D systems, Minneapolis, MN), BMP4 (5/25/50 ng/mL) (R&D ...

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

The distinct population of endothelial cells that line blood vessels in the insulin-producing "islets" of the human pancreas ...

The brain of humans and other animals is known to contribute to the protection of the body from infections. Past studies have ...

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...

Mechanistically, PGRN deficiency suppressed mitochondrial respiration, induced mitochondrial fission, and disturbed autophagy process and redox signaling, while restoration of PGRN levels in aortae ...

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