Over this time, the mitochondrial genome became reduced, retaining only 37 genes in most animal species, and growing reliant on the nuclear genome to fulfill the organelle’s primary function—to ...

Acute pancreatitis (AP) is a gastrointestinal disorder characterized by inflammation and necrosis of the pancreatic acinar cells. Mitochondrial homeostasis is key to energy metabolism and redox ...

researchers from the United States of America investigated how cells separate competing metabolic pathways within mitochondria, namely oxidative phosphorylation (OXPHOS) and reductive synthesis of ...

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes ...

“We’re using vague terms like mitochondrial dysfunction, and it’s not clear what that means,” said Murphy. Instead, descriptions should focus on the specific process that has gone awry, such as ...

Mitoribosomes are present in the mitochondria of all eukaryotic cells. Their function is to allow the translation of mitochondrial mRNA that exclusively encodes components of the oxidative ...