C&EN11h
If insulin can’t get into tissues, it can’t act
If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...
GEN3d
Obesity-Linked Hormone Adrenomedullin Disrupts Insulin Signaling
Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.
News Medical on MSN4d
A pathway that contributes to insulin resistance can be targeted, mouse study shows
The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...
News Medical on MSN5d
How olive oil bioactives regulate genes linked to insulin resistance
Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...
Nature5d
Remarkable leukemogenic potency and quality of a constitutively active neurotrophin receptor, ΔTrkA
in the presence of signal transduction inhibitors. The assays were plated as duplicates or quadruplicates, and colonies were counted on day 6. Inhibition of cell growth was also investigated in ...
eLife6d
Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice
Pathway enrichment analysis enables us to determine the major biochemical metabolic pathways and signaling transduction pathways that are implicated by the differential metabolites. (a) The ...