If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...

Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...

Cells have proteins called receptors ... Different receptors are specific for different molecules. Dopamine receptors bind dopamine, insulin receptors bind insulin, nerve growth factor receptors ...

"Rising ceramides in the cell are responsible for inflammation, insulin resistance ... PAQR4, a receptor in the same protein family, has an extremely similar structure; however, its function ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.

G-protein coupled receptors regulate hormone secretions in the pancreas. Learn how the complex signaling features of these receptors are illuminating diabetes research. Diabetes results from ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

The German team “serendipitously” identified a link between the activation of G-protein coupled receptors and cAMP formation, where the latter inhibits insulin signaling. “Obese mice that ...