In the talk, Sanil Bhatia moved from the function of HSP90 in cancer cells to inhibitors that target HSP90. He highlighted inhibitors that target the dimerization of HSP90 as these are designed to ...
2Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan. 6Department of Immunogenomic Medicine, Research ...
We evaluated the efficacy of heat shock protein 90 (Hsp90) inhibition as a novel approach to inhibition of aberrant transforming growth factor (TGF)-β signalling and for the treatment of fibrosis in ...
Here, we describe the use of a blood–brain barrier (BBB) permissive supramolecular cationic drug vehicle comprising an inhibitor of the chaperone heat shock protein 90 (Hsp90), which sustains a ...
Kosan Biosciences has initiated a Phase I multicenter trial of an oral formulation of KOS-1022 (DMAG), a second-generation heat shock protein 90 (Hsp90) inhibitor. KOS-1022 is the first-reported Hsp90 ...
The drug candidate is a Hsp90 inhibitor linked to SN-38 via a cleavable chemical linker. SN-38 acts by targeting topoisomerase I. The drug candidate is developed based on Hsp90-inhibitor drug ...
Design, Synthesis, and Biological Evaluation of Chiral-Proline Derivatives as Novel HSP90 Inhibitors
Laboratory for Food and Medicine Homologous Natural Resources Development and Utilization, Dezhou University, Dezhou City 253023, Shandong Province, China ...
In addition, organoids with high Eif5a2 expression were shown to be sensitive to AKT inhibitors. As a final step, the team analysed two databases of human prostate cancer samples, which confirmed a ...
This can include: being rude saying things that aren’t appropriate (for example, that someone is overweight) talking to strangers undressing in public apparent loss of sexual inhibition (for example, ...
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