BMJ3d
Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis
We evaluated the efficacy of heat shock protein 90 (Hsp90) inhibition as a novel approach to inhibition of aberrant transforming growth factor (TGF)-β signalling and for the treatment of fibrosis in ...
FierceBiotech1d
Biogen axes asset from $7.3B buyout, along with Alzheimer’s and Parkinson’s prospects
BIIB143, also known as cemdomespib, was the most advanced asset to get the chop. Biogen acquired the Hsp90 modulator in 2023 through its buyout of Reata, a deal that centered on the FDA-approved ...
asco.org3d
Phase I study of the HSP90 inhibitor AUY922 in combination with capecitabine as treatment for patients with advanced solid tumors.
This material on this page is ©2025 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For more information, please ...
Alzheimer's Society2d
Loss of inhibitions and dementia
This can include: being rude saying things that aren’t appropriate (for example, that someone is overweight) talking to strangers undressing in public apparent loss of sexual inhibition (for example, ...