DUSP6 is a type of protein called a phosphatase that acts like a "switch-off" mechanism for specific signaling pathways inside cells. Its main function is to control the ERK1/2 MAPK pathway ...

The classical pathway is initiated by the interaction of C1 with IgG ... upregulating the expression of proinflammatory mediators by activating ERK1/2 and releasing extracellular ATP in monocytes or ...

which are associated with regulating ERK/mTOR pathways. Pierce® BCA Protein Assay Kit was obtained from Thermo Scientific. Bax (2772), cleaved Caspase 3 (9664), SQSTM1/p62 (5114), Beclin1 (3495), ...

Promising oral drug therapies are within reach thanks to research into the mitogen-activated protein kinase (MAPK) and affiliated pathways. Personalised heart ... developing small molecules targeting ...

Despite being the most widely used performance metric, focusing on engagement as an end in itself tends to be counterproductive. Focusing narrowly on engagement without a clear sense of how the game ...

A team of researchers from the Keck School of Medicine of USC has unlocked the details of a cellular pathway that triggers ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

An oft-repeated message is that primary aldosteronism is not rare; it is quite common. An equally urgent message is that ...