"We found that pharmacologically targeting a single kinase, CDK2, can trigger two distinct cellular responses depending on ...

Cyclin-dependent kinases (CDKs ... Based on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of proteins known as ...

Tyk Medicines Inc. has patented new cyclin-dependent kinase 2 (CDK2) and/or cyclin-dependent kinase 4 (CDK4) inhibitors reported to be useful for the treatment of cancer, infections, metabolic ...

– Updated overall survival (OS) results – a key secondary endpoint – reinforce the significant benefit of the Itovebi TM (inavolisib)-based regimen for patients with advanced PIK3CA-mutated ...

The randomised Phase II portion of the trial enrolled 65 metastatic hormone receptor positive (HR+), HER2-negative/low or triple-negative breast cancer patients who exhausted endocrine therapy ...

Media Release Marking Immutep's transition to a Phase III biotech, the Company's pivotal TACTI-004 trial in first-line non-small cell lung cancer (1L NSCLC) received first regulatory approvalMature da ...

An MTF2-containing subcomplex of Polycomb Repressive Complex 2 promotes cell cycle progression through repression of D-type cyclin expression in certain cellular contexts.

Figure 3 Cytoplasmic p21 may prevent apoptosis by inhibiting the proapoptotic ASK1 kinase ... S phase of the cell cycle. cdk inhibitors such as the p16ink4 family and the p21 family restrict the ...

This manuscript reports useful data suggesting a critical role of two cyclin-dependent kinases ... qPCR analysis of steroidogenic Star and Fads genes in ex vivo cultured Leydig cells in response to ...

Inhibition of RET by siRNA-mediated knockdown or treatment with the tyrosine kinase inhibitor selpercatinib impaired the ... 1:1000), anti-Rb (9309, 1:1000), anti-cyclin D1 (2978, 1:1000), ...

Not long after, the team produced mice with the gene for producing sAC removed ... research continues apace on selective inhibitors of another non-hormonal male contraceptive target, cyclin-dependent ...