Negative feedback pathways, depicted by dashed lines ... Acetylcholine, pituitary adenylate cyclase-activating peptide, and other neurotransmitters are released from synaptic terminals. Cytokines, ...

Background: Pituitary adenylate cyclase-activating polypeptide (PACAP ... Wnt/β-catenin is a common downstream target pathway of SOX6. We speculated that PACAP38 may suppress Wnt/β-catenin signaling ...

In a world where the quest for effective weight loss solutions has become increasingly urgent, consumers are presented with many options that often confuse them. BrickHouse Nutrition Lean emerges as a ...

These pathways represent the targets of all currently approved ... discovered in the gut that mediates smooth muscle relaxation via activation of adenylate cyclase and generation of cAMP. Despite ...

Last year, the CMS Innovation Center launched the Quality Pathway strategic initiative to strengthen the focus on quality in alternative payment models. Since it was created, the CMS Innovation ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Hope is not passive wishing but an active, dynamic process. According to Hope Theory, hope involves two components: agency and pathways. Agency is the belief in one’s capability to act ...

Objective Metabolic reprogramming plays a critical role in modulating the innate and adaptive immune response, but its role in cutaneous autoimmune diseases, such as cutaneous lupus erythematosus (CLE ...

With the approval of the soluble guanylate cyclase stimulator riociguat, an additional drug class has become available targeting a distinct molecular target in the same pathway as PDE5 inhibitors.