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FasL inhibitor speeds recovery and reduces mortality in severe COVID-19 patients
A new clinical study shows that an inhibitor of Fas ligand (FasL), also called CD95 ligand (CD95L), led to a faster recovery of COVID-19 patients and reduced mortality. On average, it took eight ...
Nature10y
Fas counter-attack–the best form of tumor defense?
A recent report demonstrated that murine AK-5 tumor cells transiently upregulated FasL when grown in the peritoneal cavity of syngeneic mice, and that this FasL upregulation coincided with ...
Nature4mon
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
Figure 2: FasL-mediated, caspase-independent cell death in T cells requires FADD. Figure 3: RIP binds to Fas and signals necrotic T cell death. Figure 4: FasL-induced, caspase-independent T cell ...