Nature12y
Activation of ERBB Receptors
EGFR has been the most extensively studied ... and it ultimately leads to phosphorylation of tyrosines on the C-terminal tail. As a general principle, ligand binding leads to dimerization and ...
Medscape11y
Reverse-Phase Protein Microarray Highlights HER2 Signaling Activation in Immunohistochemistry/FISH/HER2-Negative Breast Cancers
Reverse-phase protein microarray was used to evaluate protein levels and activation/phosphorylation status of HER family (EGFR, HER2 and HER3) and downstream signaling molecules. The analysis was ...
Lutris Pharma Secures $30 Million Financing To Advance The Development Of Biopharmaceutical To Improve Anti-Cancer Drug Effectiveness
In October 2024, Lutris successfully completed enrollment in the international phase 2 trial of LUT014 in patients with metastatic colorectal cancer (mCRC) treated with EGFRi therapy who develop ...