High levels of adrenomedullin found to promote obesity-associated insulin resistance
Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...
News Medical on MSN11h
Adrenomedullin hormone as key driver of insulin resistance in obesity-linked type 2 diabetes
Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.
C&EN1d
If insulin can’t get into tissues, it can’t act
If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...
News Medical on MSN5d
How olive oil bioactives regulate genes linked to insulin resistance
Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...
News Medical on MSN11d
Unlocking the potential of receptor-based approaches in diabetes treatment
Announcing a new article publication for BIO Integration journal.   Diabetes, a common metabolic condition, poses a substantial health burden worldwide. To revolutionize diabetes management, enhance ...
GEN4d
Obesity-Linked Hormone Adrenomedullin Disrupts Insulin Signaling
Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes.
News Medical on MSN4d
A pathway that contributes to insulin resistance can be targeted, mouse study shows
The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...
BioWorld15d
PTP1B allosteric inhibitor enhances glucose uptake in insulin resistance models
Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...