Prion diseases are characterized by abnormal folding of the host ... Although the mechanisms of cell death are likely multifaceted, one important contributing pathway is the unfolded protein response ...

They have the potential to attack the body by mistake, which is what happens in autoimmune diseases and allergies. By demonstrating how indispensable this Apex1 protein is to the destructive ...

"In the resilient group a microglia pathway that's often linked to Alzheimer's disease appeared to be less active. In addition, we saw that the so-called 'unfolded protein response,' a reaction in ...

A new study reveals that even low-dose, chronic exposure to air pollution can trigger liver inflammation, fibrosis, and metabolic disruptions, increasing the risk of fatty liver disease and other ...

Under stress, mitochondria rapidly increase their copy number—that is, the number of mitochondrial genomes in each organelle—as part of a process called the mitochondrial unfolded protein ... the ...

We are exploring the mechanisms utilized by COPII to segregate folded protein cargo from unfolded forms and ER chaperones ... arising in neurodegenerative disorders such as Parkinson’s disease, in ...

I Herantis Pharma Plc ("Herantis"), a company developing disease-modifying therapies for Parkinson’s disease, is pleased to announce an ...