Figure 2: The retinoblastoma protein phosphorylation status in normal and telomerase–expressing fibroblasts. Figure 3: Effects of UV irradiation on the expression of p53 and p21 Cip1/Waf1 ...
The two-hit hypothesis arose of out Knudson's interest in the genetic mechanisms underlying retinoblastoma, a childhood form of retinal cancer. Under normal circumstances, a population of cells in ...
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