On the left, an unactivated RTK receptor (pink) encounters a ligand (red). Upon binding, the receptor forms a complex of proteins that phosphorylate each other. In turn, this phosphorylation ...

Genetic mechanisms of resistance to kinase inhibitors include mutations in the target receptor and mutations or gene amplification of compensatory receptors or other signaling effectors.

I study and characterize the response to KRAS G12C, SOS1 and SHP2 inhibitors alone or in combination with receptor tyrosine kinase (RTK) or MEK inhibitors in different tumor types to determine the ...