Hydrocodone-acetaminophen and Percocet come with boxed warnings regarding the serious risks associated with each drug. Misuse of Vicodin or Percocet can cause addiction, overdose, or death.

However, oxycodone is considered to be a more potent opioid than hydrocodone. Percocet is a combination drug that contains both an opioid (oxycodone) and a nonopioid analgesic (acetaminophen).