Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.

The image shows Langerhans islets after chronic intermittent fasting. On the left those of an adult animal, on the right those of a young animal. The beta cells of the pancreatic Langerhans’ islets ...

The researchers investigated the impact of intermittent fasting on the beta cells. In the pancreas of mature mice, no negative effects on the beta cells were observed (here stained green).

The beta cells of the pancreas are responsible for releasing ... signal transmission and networking of beta cells with other ...

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and ...

More information: Esra Karakose et al, Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors, Cell Reports Medicine (2024). DOI ...

Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use the insulin ...

The distinct population of endothelial cells that line blood vessels in the insulin-producing "islets" of the human pancreas have been notoriously difficult to study, but Weill Cornell Medicine ...

The Seattle company said it transplanted its treatment, UP421, an allogeneic primary islet ... weeks after cell transplantation demonstrate the survival and function of pancreatic beta cells ...

Glucagon is secreted to the blood by alpha cells located in the pancreatic islet of Langerhans ... trigger insulin secretion from pancreatic beta cells, low- plasma glucose drives glucagon ...