The PDGF-signaling pathway stimulates tumor-cell proliferation, angiogenesis, and pericyte recruitment to tumor blood vessels. [9] Interestingly, a recent report showed that PDGF-BB expression is ...

PDGF-AA acted as agents of chaos, binding directly to PDGF receptors on the surface of BM-MSC. This subsequently activated the Hippo signaling pathway, which is responsible for cell regeneration, to ...

[78] Several potent non-selective tyrosine kinase inhibitors that interrupt both VEGF and PDGF signaling have been approved for cancer therapy: imatinib, sorafenib, pazopanib, sunitinib ...

Taking advantage of the urchin genome project, genes involved in PDGF signaling and the synthesis/modification ... We recently discovered evidence that a signaling pathway involving the protein ...

The authors suggest that TGF-β and PDGF direct the response of ... potential for targeting the PI3K pathway. “Targeting growth factor signaling may be an indirect method to reduce cytokine ...