The functional autocrine loop constituted by coexpression of the KIT receptor tyrosine kinase (TK) and its ligand stem cell factor was first reported in small-cell lung cancer (SCLC) tumors and ...

For the titration, a tyrosine kinase is used at concentrations ranging from 0.10 to 10 ng/well (in 20 μl), and is incubated 30 min with the biotin-tagged generic substrate supplied with the kit ...

Hoth Therapeutics, Inc. (NASDAQ: HOTH), a biopharmaceutical company dedicated to developing innovative therapies for unmet medical needs, today announced its collaboration with OnTargetx R&D Inc. to ...

Hoth Therapeutics Inc., a biopharmaceutical company committed to developing innovative therapies for unmet medical needs, has collaborated with OnTargetx R&D Inc. to accelerate research for its cancer ...

Pharmaceutical ads are difficult to avoid in American television programming and a growing number of them promote a class of ...

Sevenless, the Drosophila homologue of ROS1 (dROS1) is a receptor tyrosine kinase essential for the differentiation of photoreceptor cells and activated by binding to the GPCR Bride Of Sevenless ...

Sorafenib is an oral multikinase inhibitor that inhibits tumor growth and proliferation by interfering with several receptor tyrosine ... Flt3, c-KIT and the RAF kinase and MAPK pathways.