Nature14d
G protein-coupled receptors articles from across Nature Portfolio
G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...
Nature4y
Activation of the G alpha subunit of a G-protein-coupled receptor
G beta-gamma (purple circles), and a G-protein-coupled receptor (GPCR; light green loops). Upon receptor stimulation by a ligand called an agonist, the state of the receptor changes. G alpha ...
Royal Society of Chemistry4y
Nobel Prize for Chemistry awarded for G-protein-coupled receptors
The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...
New numbering system standardizes protein domain comparison for better research
Adhesion G protein-coupled receptors (GPCRs) are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for ...