This new intracellular pocket could be a game-changer in how we design drugs to interact with these receptors." "To provide direct evidence for binding of the molecule at different pockets of the ...

Announcing a new article publication for BIO Integration journal. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in China in December 2019, rapidly spread worldwide, ...

GPR6 is an orphan G protein-coupled receptor ... specific drugs that can reduce its activity. The experiments revealed a lipid-like molecule occupying the orthosteric ligand-binding pocket.

These molecules prevent endogenous prolactin from exerting its actions via a competitive mechanism for receptor binding ... the classical drugs used to decrease prolactin production and release ...

Drug discovery is a costly and time-intensive process, with binding free energy calculations between the potential drug ...

Psoriasis is a chronic skin disease that manifests itself mainly with skin symptoms (dryness, itching, scaly skin, abnormal patches and plaques). It affects about 2% of the population and is mediated ...

Objective: To review drug interaction studies of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and concurrent oral medications. Data Sources: PubMed was searched (to December 5, 2011 ...

Data Synthesis: Pharmacodynamic characteristics (glucocorticoid receptor binding) and lung delivery determine the relative clinical efficacy and pharmacokinetic properties (oral bioavailability ...

5 (4) A CAR controlled remotely via drugs and other small molecules puts the brakes ... also have high antigen sensitivity via the fusion of an antibody binding domain. This hybrid receptor design ...