Cure Today14d
Identifying Drivers of Exceptional Response to Immunotherapy in Metastatic RCC
In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell responses, among other factors.
GEN18h
Dysfunctional Mitochondria Trigger Retrograde Signaling that Impairs Pancreatic β-Cells
Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...
Nature3y
Cell Signaling
Most cell signals are chemical in nature. For example, prokaryotic organisms have sensors that detect nutrients and help them navigate toward food sources. In multicellular organisms, growth ...
TGF-β signaling pathway mediates neuronal-intestinal mitochondrial stress response and lipid metabolism, finds study
acts on its receptor DAF-1 located on RIM neurons to activate the downstream TGF-β Dauer signaling pathway, thereby inducing ...
Gene modification can encourage T cell growth, improving cancer treatment's success rate
Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying ...
ascopubs.org12d
Results From First-in-Human Phase I Study of a Novel CD19-1XX Chimeric Antigen Receptor With Calibrated Signaling in Large B-Cell Lymphoma
Surrogate End Points for Overall Survival in Neoadjuvant Randomized Clinical Trials for Early Breast Cancer Twenty-eight patients underwent apheresis and received CAR T cells. Sixteen and 12 patients ...
Pacylex Pharmaceuticals Presents Progress on NMT Inhibitors for Cancer at February Industry Conferences
Dr. Weickert will present Pacylex at the OBIO® Investment Summit and Early Technology Showcase February 5-7, 2025, at the Arcadian Court & Loft, Toronto Mr. Kamdar will present Pacylex at the PWMC ...