In MYCN-amplified NB cells, the half-life of N-Myc is significantly prolonged due to binding and stabilization by Aurora kinase A (Aurora-A; elevated in NB), resulting in increased steady-state ...

Their results are published in Chemical Science. Lead researcher Professor Andrew Wilson explained, "Aurora-A is an incomplete kinase, which means it relies on protein-protein interactions to ...

Cell cycle events are controlled tightly by several kinase families including CDKs, Plks, and Aurora kinases. What is interesting about these kinases is that they don't always act alone.

Image Source: Zacks Investment Research Puma Biotechnology in-licensed global development and commercialization rights for alisertib, an aurora kinase A inhibitor, from Japan’s Takeda in 2022.