Aldosterone is a steroid hormone that plays a critical role in the homeostasis of sodium, potassium and volume. Aldosterone is secreted primarily by cells of the zona glomerulosa in the adrenal ...

Primary aldosteronism treatment response was associated with higher plasma renin activity and serum potassium levels and lower aldosterone.

Urinary Sodium and Potassium, and Aldosterone Secretion before and after Guanethidine Treatment, and Six Months after Surgical Removal of the Tumor (the Stippled Areas Represent the Normal Ranges).

Aldosterone antagonists (spironolactone, eplerenone) also known as “potassium sparing diuretics” block the action of aldosterone inhibiting the reuptake of sodium and water. Normally ...

Potassium and renal function must be routinely assessed to minimize the risk of life-threatening hyperkalemia. This review discusses the role of aldosterone antagonists in the treatment of heart ...

Nursing mothers. Avoid concomitant potassium-sparing diuretics. Monitor for hyperkalemia with drugs that inhibit the renin-angiotensin-aldosterone sytem (eg, ACE inhibitors, ARBs, spironolactone ...

However, during the run-in period, one patient had to discontinue therapy because of serious hyperkalemia (serum potassium level 6.5 mmol/l) and another stopped treatment as a result of ...