Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8:15 p.m. ET. The 49ers are 2.5-point ... Night Football picks. The model, which simulates every NFL game 10,000 times, is up well ...

SANTA CLARA, Calif. -- The San Francisco 49ers suspended De'Vondre Campbell for their final three regular-season games Monday after the linebacker refused to play and then walked out of Thursday ...

SANTA CLARA, Calif. (AP) — The San Francisco 49ers suspended linebacker De’Vondre Campbell for the rest of the regular season after he refused to enter a game after losing his starting job.

Jared Goff threw for 303 yards and three touchdowns and Jahmyr Gibbs added 163 scrimmage yards and a score of his own as the Lions topped the 49ers 40-34 in Santa Clara. The win moves Detroit back ...