Clifton is a Census-designated place located in Spartanburg County in the U.S. State of South Carolina. According to the 2010 United States Census, the population was 541. Clifton is located at 34°59′10″N 81°49′13″W / 34.98611°N 81.82028°W. These coordinates place the CDP on the East side of the county, between the cities of Spartanburg and Cowpens.
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